Omics · study · 2026
Genome wide DNA methylation analysis in a prospective observational study identifies several epigenetically deregulated genes during renal replacement therapy at ESRD.
Listed in NCBI GEO
Renal replacement therapy (RRT) can be initiated in the end-stage renal disease (ESRD).
Description
Over four million people worldwide receive RRT. Haemodialysis (HD) is the most frequently employed treatment, followed by peritoneal dialysis (PD), while conservative treatment (CT) is selected more frequently for elderly individuals, particularly women.
The molecular mechanisms of ESRD-RRT, and its possible impact on cellular processes, are not yet fully understood, although recent evidence suggests a correlation between epigenetic regulation of chromatin dynamics, mainly DNA methylation, and control of gene transcription in this pathology. This investigation represents the first prospective study of epigenomic alterations during HD, PD and CT treatments in ESRD. Advanced Infinium EPIC array technology, capable of measuring levels of DNA methylation of over 850,000 CpG sites in the genome, was used in peripheral blood mononuclear cells.
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The results show an inverse relationship between the methylation levels of certain CpGs of significant genes and changes in gene expression during the different ESRD treatments. Namely, the genes FBXWD7, TMEM229B and MZF1 in CT group, NELL1, CBLN1 and EEF1D in HD group and COX11, TMCO and RSPO3 in PD group. These genes are linked to inflammation, oxidative stress, immune response, mitochondrial disorders, pericardial oedema, vascular congestion or metabolic diseases.
The findings suggest that these genes may contribute to the differing prognoses observed between the different treatment groups. The epigenomic alterations identified could contribute to the pathophysiology and prognosis of ESRD and may represent important therapeutic targets for the improvement of future treatment options.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291053 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291053 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1231468 ncbi.nlm.nih.gov/bioproject/PRJNA1231468 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- Computed tomography 50% · Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE291053 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:ct | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (50%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |