Structure · dataset · 2026
3D-printed bioresorbable scaffolds for regeneration of articular cartilage
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639892.v1
Osteoarthritis is a degenerative disease affecting synovial joints such as the knee that leads to structural changes in the articular cartilage and the subchondral bone.
Description
The current gold standard of care for severely impaired joints is total joint replacement, in which a metal or polymer prosthesis replaces the damaged joint entirely. Even though the process is well-established, there are drawbacks, like implant loosening and a 15-year lifespan that requires invasive revision surgery if the initial implant fails.
Cartilage tissue engineering has gained popularity in recent years as an alternative method to replace damaged tissue that could provide long-term benefits over current treatment methods. However, having scaffolds that could provide a well-rounded functionality for cartilage tissue engineering has been an unmet challenge in the literature. The overall aim of this thesis was to develop scaffolds with biomechanical properties similar to native cartilage and evaluate their cartilage regenerative potential through in vitro studies.
Read the rest (2 more)
This thesis set out to investigate the following objectives: 1) developing 3D-printed biomechanically comparable scaffolds and assessing their degradation characteristics in vitro; 2) In vitro assessment of the chondrogenic capacity of composite constructs fabricated by reinforcing hydrogels with the 3D-printed scaffolds; 3) evaluating cell culture factors contributing to chondrogenesis of the composite constructs. In conclusion, this thesis proposes a biomechanically comparable porous scaffold fabricated from 3D printing PLLGA 85:15 as a functional solution for cartilage tissue engineering.
The scaffold degrades within the cartilage regeneration timeframe, promotes chondrogenesis by reinforcing a hydrogel, and maintains cell viability. It is anticipated that the novel characteristics of PLLGA 85:15 can be used as a potential medical device in the future to treat articular cartilage defects and stop the progression of osteoarthritis.<br><br>
Links
Where it is published
- DOI doi.org/10.17034/32639892.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Engineering · Engineering · Engineering · Materials Science · Materials Science · Materials Science
- Inferred from text
- Biomedical engineering 73% · Disease 75%
Provenance · 3 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639892 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639892 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639892 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:4003 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:engineering | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |