Omics · study · 2026
Low-intensity Pulsed Ultrasound regulates osteoclasts mitochondrial function in the treatment of diabetic periodontitis [scRNA-seq]
Listed in NCBI GEO
Periodontitis and type Ⅱ diabetes mellitus (T2D) have emerged as prevalent global chronic diseases, with a bidirectional relationship existing between them.
Description
Individuals with periodontitis and T2D are susceptible to tooth loss, primarily attributed to alveolar bone resorption resulting from excessive osteoclasts (OC) differentiation. Although low-intensity pulsed ultrasound (LIPUS) is an established treatment method for bone-related conditions, its mechanism of action on OC remains unclear.
The aim of this research is to examine the effects and mechanism of on OC within a diabetic inflammatory environment. In summary, our data explored how LIPUS affects OC in the inflammatory environment of diabetes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE280nnn/GSE280908 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280908 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1181024 ncbi.nlm.nih.gov/bioproject/PRJNA1181024 ↗
project · from NCBI GEO
- PubMed 42474035 pubmed.ncbi.nlm.nih.gov/42474035 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Single-cell RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE280908 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |