Data · dataset · 2026
<p>Cell cycle-associated variation of histones, kinases, and nucleotide metabolism-related proteins in the T. cruzi nuclear proteome.</p>
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Description
<p><b>(A)</b> Relative abundance of canonical histones during G1/S, S, and G2/M phases. <b>(B)</b> Relative abundance of histone variants during G1/S, S, and G2/M phases. <b>(C)</b> Relative abundance profiles of selected kinases detected in the nuclear proteome, including metabolic kinases and signaling-associated kinases. <b>(D)</b> Relative abundance of selected proteins associated with nucleotide metabolism across the cell cycle.
Statistical significance was assessed by ANOVA (*p < 0.05, **p < 0.01). <b>(E)</b> Schematic representation of nucleotide metabolism in T. cruzi, including pyrimidine de novo and salvage pathways and the purine salvage pathway. Enzymes are color-coded according to their detection and abundance variation across the cell cycle: orange, identified but not quantified; green, no significant variation; red, increased abundance in G1/S compared with S and G2/M; gray, decreased abundance in G2/M compared with S and G1/S; and white, not detected.
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Pyrimidine metabolism: carbamoyl-phosphate synthetase II (CPSII, EC:6.3.5.5), aspartate carbamoyltransferase (ATCase, EC:2.1.3.2), dihydroorotase (DHOase, EC:3.5.2.3), dihydroorotate dehydrogenase (DHODH, EC:1.3.98.1), orotate phosphoribosyltransferase (OPRT, EC:2.4.2.10), orotidine-5-phosphate decarboxylase (OMP, EC:4.1.1.23), uracil phosphoribosyltransferase (UPT, EC:2.4.2.9), UMP-CMP kinase 2 (UMPK, EC:2.7.4.22), cytidine triphosphate synthase (CTPS, EC:6.3.4.2), uridine-cytidine kinase (UCK, EC:2.7.1.48), nucleoside diphosphate kinase (NDK, EC:2.7.4.6), ribonucleoside-diphosphate reductase (RNR, EC:1.17.4.1), 5′-deoxynucleotidase (5′DN, EC:3.1.3.89), thymidylate kinase (TK, EC:2.7.4.9), and phosphoribosylpyrophosphate synthetase (PRPS, EC:2.7.6.1).
Purine metabolism: inosine-adenosine-guanosine-nucleoside hydrolase (IGNH, EC:3.2.2.1), hypoxanthine-guanine phosphoribosyltransferase (HGPRT, EC:2.4.2.8), inosine-5′-monophosphate dehydrogenase (IMPDH/INMD, EC:1.1.1.205), guanylate kinase (GK, EC:2.7.4.8), adenosine kinase (AK, EC:2.7.1.20), and adenylate kinase (ADK, EC:2.7.4.3). Abbreviations: PRPP, phosphoribosyl pyrophosphate; AMP, adenosine monophosphate; ADP, adenosine diphosphate; ATP, adenosine triphosphate; dADP, deoxyadenosine diphosphate; dATP, deoxyadenosine triphosphate; IMP, inosine monophosphate; GMP, guanosine monophosphate; GDP, guanosine diphosphate; GTP, guanosine triphosphate; dGDP, deoxyguanosine diphosphate; dGTP, deoxyguanosine triphosphate; XMP, xanthosine monophosphate; UMP, uridine monophosphate; UDP, uridine diphosphate; UTP, uridine triphosphate; CMP, cytidine monophosphate; CDP, cytidine diphosphate; CTP, cytidine triphosphate; dCDP, deoxycytidine diphosphate; dCTP, deoxycytidine triphosphate; dTDP, deoxythymidine diphosphate; dTTP, deoxythymidine triphosphate.</p>
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Where it is published
- DOI doi.org/10.1371/journal.pntd.0013299.g002 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 1 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34017749 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:310505 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['gene expression'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3102 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Computational Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:physics | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |