Table 1_Neurological involvement in localized scleroderma: a systematic review of clinical manifestations and neuroimaging findings.docx

Apart from the disfiguring craniofacial lesions, the extracutaneous involvement in LoS has been increasingly recognized and studied. Among all, neurological involvement is common and worth special attention.</p>Objectives<p>This systematic review summarizes the neurological symptoms, neuroimaging findings, and other complementary examination results of LoS.</p>Methods<p>Records were retrieved using keywords related to the disease, neurological symptoms, and neurological examinations.

After excluding irrelevant literature, case reports, case series, and cohort studies were included. A statistical analysis was performed, focusing on central and peripheral nervous system symptoms, neuroimaging manifestations, and other complementary examination results.</p>Results<p>A total of 242 topic-related publications reporting data on nearly 3,500 patients were finally included. The top ranked central nervous system symptoms of LoS were headache and migraine, epilepsy, and hemiparesis.