PDGF signaling regulates the adipocyte-to-fibroblast transition in wound healing

How such transitions are regulated, and whether they exemplify cell plasticity or merely a transient suppression of adipocyte features, is unclear. Fibroblasts express platelet-derived growth factor receptors (Pdgfra and Pdgfrb) while adipocytes express adiponectin (Adipoq).

We developed two-step lineage tracing to label Pdgfra+ and Pdgfrb+ cells originating from Adipoq+ adipocytes. Adipocyte-derived Pdgfr+ cells (ADPCs) are induced adjacent to skin wounds and contribute to the wound fibroblast population. ADPCs lose adipocyte characteristics and acquire fibroblast characteristics including collagen expression, smooth muscle actin expression, and cell proliferation.