Table · dataset · 2026
Supplementary file 1_A multifunctional Fe3O4@Au-HPG-Glc theranostic platform for MRI/fluorescence-guided photothermal ablation of osteosarcoma.docx
Listed in figshare
Background<p>The clinical management of osteosarcoma is challenged by its aggressive growth and deep anatomical location.
Description
Photothermal therapy offers a minimally invasive approach through localized thermal ablation, but its effectiveness is constrained by poor tissue penetration and inaccurate targeting of deep tumors without real-time guidance.</p>Methods<p>We synthesized flower-like Fe<sub>3</sub>O<sub>4</sub>@Au nanoparticles coated with hyperbranched polyglycerol (HPG) and conjugated with glucose (Glc) (Fe<sub>3</sub>O<sub>4</sub>@Au-HPG-Glc).
In an osteosarcoma mouse model, the photothermal efficacy of the nanoprobes was evaluated by comparing two groups: the control group receiving phosphate-buffered saline plus laser irradiation (phosphate-buffered saline (PBS) + Laser) and the treatment group receiving Fe<sub>3</sub>O<sub>4</sub>@Au-HPG-Glc nanoprobes plus laser irradiation (NPs + Laser). Intratumoral temperature was monitored by infrared thermography, with longitudinal tracking of tumor volume and body weight.
Read the rest (3 more)
Major organs were examined by H&E staining. Tumor accumulation was assessed via whole-body fluorescence and T<sub>2</sub>-weighted magnetic resonance imaging (MRI); pharmacokinetics and biodistribution were quantified by inductively coupled plasma mass spectrometry (ICP-MS).</p>Results<p>The NPs + Laser regimen produced rapid intratumoral heating during the 0–4 min irradiation window and significantly delayed tumor growth compared with the PBS + Laser control group, with stable body weight and no overt organ lesions on H&E staining.
Whole-body fluorescence and T<sub>2</sub>-weighted MRI confirmed tumor-site accumulation of the nanoprobes. ICP-MS-based pharmacokinetic and biodistribution analyses provided quantitative exposure context, including systemic clearance, reticuloendothelial system capture, and measurable tumor uptake. Together, these data facilitated interpretation of the subsequent photothermal response.</p>Discussion<p>Flower-like Fe<sub>3</sub>O<sub>4</sub>@Au-HPG-Glc enables image-guided photothermal treatment in an osteosarcoma model, supported by quantitative pharmacokinetic and biodistribution measurements and an acceptable short-course safety profile.
This work establishes a clear imaging-exposure-response relationship and provides a strong foundation for further optimization of magnetic-optical combination strategies in precision cancer therapy.</p>
Links
Where it is published
- DOI doi.org/10.3389/fbioe.2026.1868939.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Medicine & Health · Ocean & Atmospheric Science · Social Science
- Inferred from text
- Biomedical engineering 69% · Cancer 75% · Imaging 75% · Longitudinal study 65% · Magnetic resonance imaging 75% · Mass spectrometry 75%
Provenance · 1 source records, 22 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33770917 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:4003 | enrichment · figshare com | taxonomy-embedding@1.0.0 | title+keywords+description (69%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:imaging | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:mass-spectrometry | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:mri | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |