Data · dataset · 2022
A dataset of the effect of BDE-153 on glucose and lipid metabolism in mice
Listed in ScienceDB
This is a dataset on the effects of BDE-153 on glucose and lipid metabolism in mice.
Description
Adult mice were randomly assigned to six different groups (6 mice in each group): low, medium-low, medium, medium-high, high and control group, corresponding to 5, 25, 50, 100 and 200 mg / kg of BDE-153 dose respectively. The control group was given corn oil.
Mice in each group were continuously gavaged at a speed of 0.1 ml / 10 g body weight for 4 weeks. At the end of the second week of exposure, mice in each group fasted for 8 hours and underwent intraperitoneal glucose tolerance test (IPGTT). The mRNA and protein expression levels of Leptin, adiponectin, PPARγ and AMPKα were measured after 4 weeks of BDE-153 exposure.
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At the same time, biochemical indexes were also measured. The histomorphological changes of liver and pancreas were observed. Our results suggest that BDE-153 may interfere with the secretion of adipokines and insulin sensitivity by affecting the expression of PPARγ and AMPKα, which play a key role in glucose and lipid metabolism, leading to the occurrence of glucose and lipid metabolism disorder.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.01769 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Biochemistry and cell biology 69%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.01769 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (69%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |