Omics · study · 2026
Depletion of DIS3 from human cell lines
Listed in NCBI GEO
DIS3 is a 3’ to 5’ exoribonuclease responsible for degradation of multiple RNA targets.
Description
Most reports in human cells focus on its function in RNA surveillance in the nucleus. However, a small fraction of DIS3 can be also found in cytoplasm.
Thus, the focus of this experiment was to identify the cytoplasmic targets of DIS3. Using rapid, auxin inducible, degradation of DIS3 protein and subcellular fractionation, we were able to identify RNA accumulated in cytoplasm of human cells upon DIS3 depletion. The raw data and counts for annotated and non-annotated transcripts resulting from this experiment are provided.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE188nnn/GSE188195 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE188195 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA777897 ncbi.nlm.nih.gov/bioproject/PRJNA777897 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE188195 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |