Mendelian randomization study of causal link from gut microbiota to gout

The result of IVW was deemed as the primary result. Moreover, quantifying instrumental variable heterogeneity was done using Cochran's Q statistics. Finally, reverse-direction MR analysis were performed to rule out the possibility of reverse associations.Results Inverse variance weighted estimates suggested that Bacteroidia class (OR=1.28,95%CI=1.06-1.56,P=1.2×10-2), Streptococcaceae family (OR=1.22,95%CI=1.00-1.48,P=4.5×10-2), Anaerostipes genus (OR=1.27,95%CI=1.05-1.53,P=1.3×10-2), Ruminococcus2 genus (OR=1.16,95%CI=1.01-1.33,P=4.2×10-2), Streptococcus genus (OR=1.23,95%CI=1.01-1.50,P=3.8×10-2), Bacteroidales order (OR=1.28,95%CI=1.06-1.56,P=1.2×10-2) and Bacteroidetes phylum (OR=1.33,95%CI=1.08-1.64,P=7.3×10-3) were potentially associated with a higher risk gout, while Eubacteriumhalliigroup genus (OR=0.81,95%CI=0.68-0.96,P=1.5×10-2), RuminococcaceaeUCG010 genus (OR=0.78,95%CI=0.63-0.97,P=2.3×10-2), Subdoligranulum genus (OR=0.83,95%CI=0.69-1.00,P=4.7×10-2) were protective factors for gout.Conclusions There is a causal relationship between gut microbiota and the risk of gout.

Bacteroidia class, Streptococcaceae family, Anaerostipes genus, Ruminococcus2 genus, Streptococcus genus, Bacteroidales order and Bacteroidetes phylum were potentially associated with a higher risk gout. Eubacteriumhalliigroup genus, RuminococcaceaeUCG010 genus, Subdoligranulum genus were protective factors for gout.