Porous amine-based polymers and iron oxide nano particles incorporated with photoresponsive N(S)-nitroso or hydroresponsive N-diazeniumdiolate functional groups for antimicrobial nitric oxide delivery

Despite studies on various low molecular weight NO donors like S-nitrosothiol, N-nitrosamine, and N-diazeniumdiolate having been reported, their limited NO storage capacity and poor stability have impeded their clinical applicability. In this thesis, our primary aim was to explore the potential of porous organic polymers (POPs) for storing and releasing exogenous nitric oxide in a controlled manner for medical applications.

Several series of POPs containing secondary amine groups (-NH-) were synthesised based on the monomer 2,4,6-tris-(chloromethyl)-mesitylene (TCM) with diamines and the monomer melamine (MA) with aldehydes. These polymers were modified through nitrosation or diazeniumdiolation reactions, resulting in porous N-nitroso polymers (PNPs) or N-diazeniumdiolate polymers (PDPs), respectively. NO was stored in the polymers in the forms of N-nitroso and N-diazeniumdiolate functionalities.