Raster · study · 2026
Spatial compartmentalization shapes distinct germinal center states during respiratory viral infection
Listed in NCBI GEO
Germinal centers (GCs) typically form within the lymph node cortex, but whether proliferating B-cell aggregates in the medulla engage GC-associated programs remains unclear.
Description
In this study, mediastinal lymph nodes from SARS-CoV-2-infected cynomolgus macaques were analyzed using Xenium spatial transcriptomics to characterize conventional cortical GCs (cGCs) and LYVE1-associated medullary GC structures (mGCs). A 377-target Xenium Human Multi-Cancer Panel was used to profile their transcriptional, cellular, and spatial features.
The dataset enables comparison of GC organization across distinct anatomical compartments within lung-draining lymph nodes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346722 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346722 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1526279 ncbi.nlm.nih.gov/bioproject/PRJNA1526279 ↗
project · from NCBI GEO
Topics
- Stated by source
- Other
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346722 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |