Omics · study · 2026
Effects of SIK3 KO on the transcriptome in CA1 region
Listed in NCBI GEO
SIK3 is reported to regulate sleep in mice, but it's unclear how SIK3 works at the synapse in the brain.
Description
Here, to explore the potential effects of endogenous SIK3 on the global transcriptome, in-vivo deletion of SIK3 was achieved by CRISPR KO in the CA1 region of Cas9 mice. The CA1 tissues were dissected and analyzed by bulk RNAseq.
The result shows that in-vivo deletion of SIK3 induces a minor change in the transcriptome, suggesting a transcription-independent mechanism for SIK3.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278753 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278753 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1168572 ncbi.nlm.nih.gov/bioproject/PRJNA1168572 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE278753 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |