Omics · study · 2026
Decitabine-induced CD38 upregulation augments daratumumab activity in xenograft T-ALL
Listed in NCBI GEO
This study investigates epigenetic regulation of CD38 in T-cell acute lymphoblastic leukemia (T-ALL) and the effect of decitabine (DEC) on CD38 promoter methylation and CD38 expression.
Description
Genome-wide DNA methylation profiling was performed in T-ALL cell lines treated with DEC or DMSO and in baseline T-ALL patient-derived xenograft (PDX) samples using the Illumina Infinium MethylationEPIC BeadChip v2.0.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347263 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347263 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1529224 ncbi.nlm.nih.gov/bioproject/PRJNA1529224 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE347263 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |