<p>Progression criteria for feasibility assessment.</p>

This protocol describes plans to conduct a feasibility study in preparation for a randomized controlled trial of the Enhanced Social Prescribing intervention. Participants will be randomized on a 1:1 ratio to usual care (brochure) or Enhanced Social Prescribing (intervention). We will recruit 36 participants from two rural and rural-serving primary care practices in the Northwest U.S..

Eligible individuals are age 18 or older, screen positive for loneliness on the 3-item UCLA Loneliness Scale, received a diagnosis of cancer in the past seven years, and speak English. The Enhanced Social Prescribing intervention meets one hour weekly for nine weeks. The primary outcome is participant-reported loneliness as measured by the UCLA Loneliness Scale.

Secondary outcomes include participant reported social connection, self-efficacy, quality of life. Self-reported receipt of guideline concordant cancer survivorship care is an exploratory outcome. We will also measure Reach, Implementation, and Acceptability/Appropriateness of the Enhanced Social Support intervention.

Using an intent to treat analysis, participants will be analyzed according to their assigned group. We will use linear mixed models to estimate differences between the intervention arm and control arm, and changes in outcomes over the study period. This study protocol is registered at clinicaltrials.gov (NCT07418437).</p> <p>Anticipated results</p><p>We anticipate successful recruitment of 36 participants and delivery of the Enhanced Social Prescribing intervention to 18 participants.</p> <p>Discussion</p><p>This study will demonstrate the feasibility of testing the Enhanced Social Prescribing intervention and provide preliminary data and procedures for a larger-scale randomized controlled trial to test the effectiveness and study the implementation of Enhanced Social Prescribing.</p></div>