Data · dataset · 2026
Rice Bran Insoluble Dietary Fiber and Its Bound Polyphenols Alleviate Colitis by Regulating the Autophagy-NLRP3 Inflammasome Axis
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1021/acs.jafc.6c06416.s001
Although dietary fiber alleviates colonic inflammation, most studies have focused on carbohydrate components, neglecting bound polyphenols (BPs).
Description
Rice bran insoluble dietary fiber (RIDF), rich in BPs, improves colitis; however, how BPs work and their specific contributions remain elusive. Our study demonstrates that BPs are important contributors of RIDF in alleviating colitis.
Relative to rice bran dietary fiber without BPs (RIDF_DF), RIDF markedly ameliorated colitis symptoms, mitigated endoplasmic reticulum stress (ER stress), restored the gut microbiome and metabolites, and blocked the PI3K/Akt/mTOR cascade and NLRP3 inflammasome activation. 3-MA abolished, whereas RAPA restored, these protective effects via the autophagy-NLRP3 axis, identifying this axis as an important hub. Collectively, BPs served as an important functional component of RIDF.
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They ameliorated colitis by activating the autophagy-NLRP3 axis, which suppressed ER stress, repaired the intestinal barrier, and restored the gut microbiome and metabolome.
Links
Where it is published
- DOI doi.org/10.1021/acs.jafc.6c06416.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Biochemistry and cell biology · Biochemistry and cell biology · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Immunology · Immunology · Immunology · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Social Science · Social Science · Social Science · Sociology · Sociology · Sociology
Provenance · 3 source records, 26 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34046542 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34046542 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34046542 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:group:3101 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3204 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:3204 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:4410 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |