Data · dataset · 2025
Segmented filamentous bacteria confer protection against norovirus infection through enhanced viral clearance, immune modulation, and intestinal barrier function
Listed in ScienceDB
we demonstrate that SFB profoundly accelerates viral clearance.
Description
SFB-colonized mice exhibited significantly reduced fecal viral loads by day 5 post-infection (dpi) compared to GF and control bacteria mice (p < 0.001), reaching near-baseline levels by day 10. This enhanced viral control correlated with markedly attenuated morbidity; SFB mice experienced minimal weight loss and rapid recovery, while GF and control mice suffered severe weight loss and delayed recovery (p < 0.001).
At peak infection (3 dpi), SFB colonization significantly suppressed viral replication in feces and tissues and attenuated intestinal pathology. SFB also preserved barrier integrity, evidenced by reduced serum FITC-dextran. Mechanistically, SFB induced a distinctive antiviral cytokine profile, characterized by elevated IFN-λ and IL-22, while tempering IFN-γ increases.
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Protection was dose-dependent, with pre-infection SFB abundance strongly inversely correlating with day 3 viral load and pathology. Integrated multi-parameter and principal component analyses revealed a unique SFB-driven protective state, featuring accelerated clearance, reduced pathology/inflammation, barrier preservation, and elevated protective cytokines, establishing a pre-primed mucosal environment.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.27202 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Related
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.27202 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |