Radiation Induces Persistent Dysregulation and Functional Impairment in CD8+ T Cell Immunity

Uncertainties remain regarding the long-lasting consequences on T cell immunity in acute-radiation-syndrome survivors and the underlying mechanisms. Here, we investigated delayed effects of acute radiation exposure on CD8+ T cell immunity using the Listeria monocytogenes infection model.

Impaired CD8+ T cells activation, reduced terminal effector formation upon infection, and exacerbated listeriosis were found in mice at four weeks post-irradiation with sublethal doses. To elucidate how radiation affects the functionality of CD8+ T cells at various differentiation stages, we performed single-cell transcriptomic profiling. Irradiation altered cluster distribution pre-infection and impaired terminal effector and memory precursor effector formation post-infection.