Investigating immune-modulating polysaccharides as potential therapies for Alzheimer’s disease (AD)

In vivo studies confirmed SCA’s safety and demonstrated its ability to enhance cytokine responses and improve gut microbiome health, which may influence AD pathology via the gut-brain axis. Additionally, screening of other plant sources found that only hemp polysaccharides activated immune cells, which needs further studies in future. This thesis highlights an arabinan from Sida cordifolia as a promising immunomodulator with potential therapeutic applications for AD, particularly through enhancing immune responses and regulating gut microbiota.

Further studies, including complete clarification of the mechanisms of action of SCA in more cell models and animal models and investigation of the long-term effects of SCA both in vitro and in vivo, are needed in the future before conducting the clinical trials.<br><br><i>Thesis is embargoed until 31st December 2029</i>.<br><br>