DSRT, affinity proteomics, and single-cell surface spatial proteomics in patient with acute myeloid leukemia at diagnosis

This repository contains multi-omic data generated on FLT3 mutant and wild-type AML patients. The datasets consist of selective drug sensitivity scores, soluble protein levels, and spatial proteomics data, along with annotation files linking patient IDs across datasets and drug classifications.

Data processing methods and software dependencies are specified for each dataset. File List: - sDSS.csv : sDSS table with response to 528 drug perturbations in FLT3 mutant patients. - sDSS_FLT3i.csv : sDSS table with response to 8 FLT3i in FLT3 mutant and wild type patients. - olink_NPX.csv : Soluble protein data table for 17 FLT3 mutant patients. - pixelgen.RData : RData file containing a merged Seurat object with single-cell spatial proteomics data for 6 FLT3 mutant patients. - annotation.csv : Annotation file for all samples.