Data Sheet 1_Controlled low central venous pressure after cardiopulmonary bypass reduces acute kidney injury following cardiac surgery: a randomized controlled trial.docx

There were fewer patients with postoperative AKI in the CLCVP group [114 (44.9%)] compared with the control group [150 (59. 8%)] [Absolute risk reduction (ARR): −14.9%; 95% confidence interval [CI]: (−23. 5%, −6. 3%); P = 0. 001]. Eight (3.1%) participants in the CLCVP group and 14 (5.6%) participants in the control group developed AKI of Stage 2 and above [ARR: −2. 4%; 95% CI: (−6. 0, 1. 1%); P = 0. 263]. This reduction was primarily driven by a lower incidence of Stage 1 AKI, whereas the incidence of Stage 2 or higher AKI did not differ significantly between groups.

Median time-weighted CVP was lower in the CLCVP group (6.7 mm Hg vs. 8.1 mm Hg, P < 0. 001).</p>Conclusion<p>This randomized clinical trial demonstrated that cardiac surgery patients with CLCVP exhibited lower CVP and fewer postoperative kidney injuries compared to those receiving usual care.</p>Clinical Trial Registration<p>clinicaltrials.gov/study/NCT05855954, identifier NCT05855954.</p>