The data of study about the chitosan-selenium nanoparticles on depression-like behaviour induced by fluoride in mice via JAK2-STAT3 pathway

However, the expressions of p-JAK2 and p-STAT3 were increased in the F group compared to their respective total proteins, indicating that F affected JAK2 and STAT3 and its phosphorylation form, promoting the activation of the JAK2-STAT3 signaling pathway in Raw data 41-42. F and 2 mg/kg·bw CS-SeNPs both enhanced the protein expression levels of IL-1β (1.623 times, 2.089 times) and IL-6 (2.05 times, 4.556 times) whereas 1 mg/kg·bw CS-SeNPs diminished the IL-1β secretion induced by F in Raw data 44-45. 1 mg/kg·bw CS-SeNPs diminished F-enhanced phosphorylation of STAT3, significantly reduced F-induced IL-1β as well as IL-6 production, indicating that 1 mg/kg·bw CS-SeNPs alleviated cortical inflammatory impairment triggered by F through the JAK2/STAT3 signaling pathway.

These data provide credible data support for related pathway studies for comparison or analysis.