NCL Data2026 · Sequencing
Data Sheet 1_Comparison of three routine methods for the identification of Kerstersia gyiorum from routine diagnostics and review of the literature.pdfIntroduction<p>Since its first description in 2003, clinical case reports have repeatedly documented that the bacterial species Kerstersia gyiorum is a human pathogen. K. gyiorum has been described in the context of wound and middle ear infections, has been found in urine samples, and has even been recognized as a causative agent of septicemia. However, the pathogenic potential of K. gyiorum canno
NCL Data2026 · Sequencing
DataSheet1_Diversity of eukaryote plankton and phycotoxins along the West Kalaallit Nunaat (Greenland) coast.zip<p>The West Kallaallit Nunaat (Greenland) coast, characterized by a variety of fjords, bays, and channels influenced by glacier melting and Atlantic and Arctic waters, is one of the most affected ecosystems by climate change. Here, we combine oceanography, optics, microscopy, high throughput sequencing, microalgal strain establishments, and state-of-the-art analytical methods to fully characterize
NCL Data2026 · Sequencing
Table1_Diversity of eukaryote plankton and phycotoxins along the West Kalaallit Nunaat (Greenland) coast.xlsx<p>The West Kallaallit Nunaat (Greenland) coast, characterized by a variety of fjords, bays, and channels influenced by glacier melting and Atlantic and Arctic waters, is one of the most affected ecosystems by climate change. Here, we combine oceanography, optics, microscopy, high throughput sequencing, microalgal strain establishments, and state-of-the-art analytical methods to fully characterize
Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Sequencing
Differentially expressed LncRNAs in the lung tissue of BPD mice<p dir="ltr"><b>Data source and experimental design</b></p><p dir="ltr">This dataset contains transcriptomic data from lung tissues of a neonatal mouse model of bronchopulmonary dysplasia (BPD). BPD was induced in newborn C57BL/6 mice by intranasal administration of lipopolysaccharide (LPS; 3 μg/10 μL) on postnatal days 3, 5, 7, and 10. Control mice received an equal volume of saline. Lung tissues
ZivaHub + Deakin Research Online + DMU Figshare2026 · Sequencing
Pathogenomic analysis and molecular diagnosis of microbial keratitisIntroduction: Microbial keratitis (MK) is a serious infection of the cornea and a leading cause of monocular blindness globally. Incidence rates of MK are increasing due to a rise in associated risk factors such as contact lens use. To guide selection of the most appropriate antimicrobial therapy and ensure the best possible visual outcome for the patient, it is critical for ophthalmologists to ra
ZivaHub + Deakin Research Online + DMU Figshare2026 · Sequencing
From taxa to transcripts: investigating the snail holobiont in the context of helminth infectionHelminth parasites have complex life cycles that often require intermediate invertebrate hosts, such as freshwater snails. While much is known about the immunology and pathology of helminth infections, the role of the host-associated microbiome in these interactions remains underexplored. This thesis investigates the dynamic interplay between schistosome parasites, their snail hosts, and the host
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · Sequencing · unknown
A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disordersThe adaptive immune system provides antigen-specific immune responses through B and T lymphocytes (B and T cells) with specialised cell surface receptors. Antigens are developed de novo for specific antigen-mediated immune responses using recombination from vast repertoires and affinity maturation for diversification. Somatic hypermutation (SHM) is a B cell specific affinity maturation process whe
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · Sequencing · unknown
Clinical and microbiological endpoints in chronic airway diseasesPeople with bronchiectasis and cystic fibrosis(CF)frequently suffer from recurrent infective pulmonary exacerbations (PEx) which lead to a progressive loss of lung function, reduced quality of life and increased morbidity and mortality. Determining how bacterial load and community composition changes with time may improve our understanding of the natural history of these chronic airway diseases. <
ZivaHub + Deakin Research Online + DMU Figshare2026 · RNA sequencing
Simplifying transcriptomic profiling and molecular subtyping of colorectal cancerWe hypothesised that the use of a high-throughput RNA-sequencing (RNA-seq) technology paired with an easy-to-use data analysis application could open the field of transcriptomic subtyping to a broader user base. TempO-Seq is particularly amenable to clinically relevant samples such as FFPE and remains an extremely high throughput sequencing technology. This thesis investigates the utility of the T
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · Sequencing · unknown
Molecular diagnostic approaches to the detection, discovery and genotyping of emerging and endemic viruses circulating in Northern Ireland livestock and wildlifeEndemic and emerging viruses are essential to study in order to understand their prevalence and disease association within Northern Ireland’s livestock and wildlife as, they may be considered an important risk factor to food security, food safety and public health. In recent decades, the prevalence of viral zoonotic pathogens transmitted from animals to humans is currently creating an increasing s
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · RNA sequencing · unknown
Implementation of global miRNA biomarker discovery in human plasmaPrecision medicine is improving health outcomes by tailoring patient care to specific individuals. The improved patient stratification needed to support further implementation of precision medicine will require developments in molecular diagnostics and identification of novel biomarkers. Small non-coding RNAs, specifically miRNAs, have been shown to exist extracellularly and are stable in biofluid
ZivaHub + Deakin Research Online + DMU Figshare2026 · Genome sequencing · unknown
Bovine TB: reconstructing the molecular evolution of Mycobacterium bovisBovine tuberculosis (bTB), caused by Mycobacterium bovis, remains a significant challenge in Ireland, affecting cattle, wildlife, and agricultural trade despite decades of control measures. This thesis employs genomic tools to enhance our understanding of M. bovis evolution and epidemiology, with the goal of refining bTB surveillance and management strategies. By integrating whole-genome sequence
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · Sequencing · unknown
Molecular and genetic characterisation of contralateral breast cancer (CBC): opportunities for personalised surgeryThis thesis outlines a molecular epidemiology and genetic sequencing study carried out to investigate the relationship between primary and contralateral breast cancers (CBCs). Additionally, given the known risk factors for CBC development of young age at primary diagnosis and significant family history, the genetic predisposition of the CBC cohort was assessed.<br><br>Firstly, the population of wo
ZivaHub + Deakin Research Online + DMU Figshare2026 · Sequencing · unknown
Relationship between antibiotic treatment and clinical outcome in people with bronchiectasisIn bronchiectasis (BE), chronic bacterial infection contributes to pulmonary exacerbations, clinical decline, and increased morbidity and mortality. Bacterial load correlates with airway inflammation and exacerbation risk, supporting the use of long-term inhaled antibiotics. While microbial culture remains the gold standard for pathogen quantification, molecular methods such as quantitative PCR (q
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · RNA sequencing · unknown
Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retinaDiabetic retinopathy (DR) is the most frequently occurring microvascular complication of diabetes mellitus, where the later stages of the disease are often is chaemia driven which can result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, which is significantly impacted by the diabetic milieu. It has now been established that the endotheli
figshare + Loughborough Research Repository2026 · Sequencing
Data Sheet 2_Environmental DNA sampling workflow matters: testing different approaches on marine microbial assemblages in three coastal areas of Greece.xlsxIntroduction<p>Environmental DNA (eDNA) and high-throughput sequencing are now common tools for investigating marine microbial communities in coastal environments. Nevertheless, different eDNA sampling workflows are used across studies, while direct comparisons of their outputs under the same environmental and analytical framework remain limited.</p>Methods<p>We aimed to compare three eDNA samplin
figshare + Loughborough Research Repository2026 · Sequencing
Data Sheet 3_Environmental DNA sampling workflow matters: testing different approaches on marine microbial assemblages in three coastal areas of Greece.xlsxIntroduction<p>Environmental DNA (eDNA) and high-throughput sequencing are now common tools for investigating marine microbial communities in coastal environments. Nevertheless, different eDNA sampling workflows are used across studies, while direct comparisons of their outputs under the same environmental and analytical framework remain limited.</p>Methods<p>We aimed to compare three eDNA samplin
figshare + Loughborough Research Repository2026 · Sequencing
Data Sheet 1_Environmental DNA sampling workflow matters: testing different approaches on marine microbial assemblages in three coastal areas of Greece.docxIntroduction<p>Environmental DNA (eDNA) and high-throughput sequencing are now common tools for investigating marine microbial communities in coastal environments. Nevertheless, different eDNA sampling workflows are used across studies, while direct comparisons of their outputs under the same environmental and analytical framework remain limited.</p>Methods<p>We aimed to compare three eDNA samplin
figshare + Loughborough Research Repository2026 · Sequencing
Table 2_Case Report: Somatic GNAS and CACNA1D mutations responsible for adrenal cortisol-producing adenoma with multiple aldosterone-producing micronodules—concurrence of primary aldosteronism and mild autonomous cortisol secretion.docxBackground<p>The concurrent presence of primary aldosteronism (PA) and mild autonomous cortisol secretion (MACS) caused by adrenal lesions of a solitary cortisol-producing adenoma, accompanied by multiple aldosterone-producing micronodules (MAPM), is exceptionally rare. Moreover, there is a notable paucity of data regarding the molecular pathogenesis of this disease.</p>Case presentation<p>We repo
figshare + Loughborough Research Repository2026 · Sequencing
Table 3_Case Report: Somatic GNAS and CACNA1D mutations responsible for adrenal cortisol-producing adenoma with multiple aldosterone-producing micronodules—concurrence of primary aldosteronism and mild autonomous cortisol secretion.docxBackground<p>The concurrent presence of primary aldosteronism (PA) and mild autonomous cortisol secretion (MACS) caused by adrenal lesions of a solitary cortisol-producing adenoma, accompanied by multiple aldosterone-producing micronodules (MAPM), is exceptionally rare. Moreover, there is a notable paucity of data regarding the molecular pathogenesis of this disease.</p>Case presentation<p>We repo
figshare + Loughborough Research Repository2026 · Sequencing
Table 1_Case Report: Somatic GNAS and CACNA1D mutations responsible for adrenal cortisol-producing adenoma with multiple aldosterone-producing micronodules—concurrence of primary aldosteronism and mild autonomous cortisol secretion.docxBackground<p>The concurrent presence of primary aldosteronism (PA) and mild autonomous cortisol secretion (MACS) caused by adrenal lesions of a solitary cortisol-producing adenoma, accompanied by multiple aldosterone-producing micronodules (MAPM), is exceptionally rare. Moreover, there is a notable paucity of data regarding the molecular pathogenesis of this disease.</p>Case presentation<p>We repo
figshare + Loughborough Research Repository2026 · Sequencing
Table 4_Case Report: Somatic GNAS and CACNA1D mutations responsible for adrenal cortisol-producing adenoma with multiple aldosterone-producing micronodules—concurrence of primary aldosteronism and mild autonomous cortisol secretion.docxBackground<p>The concurrent presence of primary aldosteronism (PA) and mild autonomous cortisol secretion (MACS) caused by adrenal lesions of a solitary cortisol-producing adenoma, accompanied by multiple aldosterone-producing micronodules (MAPM), is exceptionally rare. Moreover, there is a notable paucity of data regarding the molecular pathogenesis of this disease.</p>Case presentation<p>We repo
figshare + Loughborough Research Repository2026 · Sequencing
Data Sheet 3_Chloroplast DNA minicircles composition, structure, and variation within Breviolum psygmophilum (Symbiodiniaceae, dinoflagellates).pdf<p>Members of the Symbiodiniaceae family of algae are symbiotic with a range of invertebrates, including members of the cnidaria phylum (jellyfish, anemones, and corals). Stony corals thrive from this relationship which permits them to construct tropical and subtropical coral reefs which support an enormous diversity of marine fauna. Symbiotic algae are vital to the health of the coral, providing
figshare + Loughborough Research Repository2026 · Sequencing
Data Sheet 1_Chloroplast DNA minicircles composition, structure, and variation within Breviolum psygmophilum (Symbiodiniaceae, dinoflagellates).pdf<p>Members of the Symbiodiniaceae family of algae are symbiotic with a range of invertebrates, including members of the cnidaria phylum (jellyfish, anemones, and corals). Stony corals thrive from this relationship which permits them to construct tropical and subtropical coral reefs which support an enormous diversity of marine fauna. Symbiotic algae are vital to the health of the coral, providing
figshare + Loughborough Research Repository2026 · Sequencing
Data Sheet 2_Chloroplast DNA minicircles composition, structure, and variation within Breviolum psygmophilum (Symbiodiniaceae, dinoflagellates).pdf<p>Members of the Symbiodiniaceae family of algae are symbiotic with a range of invertebrates, including members of the cnidaria phylum (jellyfish, anemones, and corals). Stony corals thrive from this relationship which permits them to construct tropical and subtropical coral reefs which support an enormous diversity of marine fauna. Symbiotic algae are vital to the health of the coral, providing