From taxa to transcripts: investigating the snail holobiont in the context of helminth infection

Multi-omic methods, including metagenomics, transcriptomics, and metabolomics, are assessed as tools for dissecting host–microbiome–parasite interactions at a systems level. Evidence suggests that schistosome infection drives microbial dysbiosis in snails, which may reflect or influence intermediate host physiology and immune activation. Additionally, hypotheses are proposed regarding parasite-driven microbiome manipulation and microbiota-mediated resistance.<br><br>By integrating ecological, immunological, and molecular perspectives, this thesis provides a framework for understanding the snail holobiont during helminth infection.

These insights hold potential for novel strategies in schistosomiasis control, including snail microbiome-based interventions targeting the intermediate host. <br><br><i>Thesis is embargoed until 31 July 2027.</i><br>