Associations of MMP-7 and OPN gene polymorphisms with risk of coal workers’ pneumoconiosis in a Chinese population: a case-control study

Methods

Four polymorphisms (rs10502001 in MMP-7 , rs1126772, rs11728697 and rs9138 in OPN ) were genotyped and analyzed in a case-control study of 697 CWP and 694 control subjects. Results : Our results revealed that three single nucleotide polymorphisms (SNPs, MMP-7 rs10502001, OPN rs1126772 and OPN rs11728697) were associated with increased risk of CWP under a recessive model (adjusted odds ratio [OR] = 1.80, 95% confidence interval [CI] = 1.01–3.20, p = 0.045 for MMP-7 rs10502001; adjusted OR = 2.09, 95% CI = 1.17–3.72, p = 0.013 for OPN rs1126772; adjusted OR = 2.48, 95% CI = 1.37–4.51, p = 0.003 for OPN rs11728697).

Additionally, a combined effect was observed in a dose-dependent manner with increasing numbers of risk variant alleles ( P trend = 0.003). Furthermore, logistic regression analysis revealed no significant interaction between SNPs and smoking status on CWP risk. Conclusions : Our results indicate that three functional SNPs ( MMP-7 rs10502001, OPN rs11728697 and OPN rs1126772) are associated with an increased risk of CWP in a Chinese population.