6,877 datasets

DataCite2026 · dataset

Glioma is a highly malignant brain tumor with limited treatment options. This dataset accompanies our study and contains the computed resources used with the Computational Analysis of Novel Drug Opportunities (CANDO) platform for multiscale therapeutic discovery to predict new glioma therapies. It includes the compound–protein interaction scores used to generate proteome-scale interaction signatur

DataCite2026 · dataset

Precise regulation of ion channel biophysics is an essential life process that governs electrical signaling in excitable tissues. Many ion channels including voltage-gated Na+ channels (NaVs) exist in the membrane as clusters, which show distinct biophysical behavior not predicted by single-channel measurements. In both heterologous and native systems, we report that single-channel-based predictio

DataCite2026 · Imaging

Across brain regions and species, the dynamics and balance of excitation and inhibition critically determine neuronal firing. The hippocampal dentate gyrus is a brain area thought to be strongly regulated by inhibition. In vivo, it exhibits remarkably sparse activity, a characteristic proposed to underlie computational tasks like pattern separation. Several populations of interneurons mediate stro

DataCite2026 · dataset

Neuropathic pain is a debilitating condition that lacks effective treatments. Corticotropin-releasing hormone (CRH) is associated with the central neural circuits involved in stress and pain. Here, we identified a peripheral CRH–mediated signaling axis in dorsal root ganglion (DRG) and spinal neurons underlying neuropathic pain. Spared nerve injury (SNI) in male mice increased the abundance of CRH

DataCite2026 · dataset

Mutations in superoxide dismutase 1 (SOD1) cause paralysis in familial amyotrophic lateral sclerosis and promote its misfolding into neurotoxic aggregates. Previous studies have shown that mice expressing the ALS-causing G85R variant of SOD1 develop paralysis much faster after intraspinal injection of spinal homogenates from paralyzed G85R SOD1 mice. These findings, and other studies in cell model

DataCite2026 · dataset

Pulmonary neuroendocrine cell (PNEC) hyperplasia often occurs in lung diseases, including allergic asthma. We previously reported that PNEC-derived calcitonin gene-related peptide (CGRP) likely stimulates group 2 innate lymphoid cells (ILC2), exacerbating asthma phenotypes in a mouse model. Here, we investigate the role of glial cell-line-derived neurotrophic factor (GDNF) and rearranged during tr

DataCite2026 · dataset

Demineralized bone matrix (DBM) is widely used as an alternative to autografts for repairing bone defects, but its clinical efficacy is limited by poor retention at the defect site and inadequate osteogenic capacity. Here, we developed a multifunctional carrier system aimed at improving the capacity of DBM by utilizing nanoclay-based self-assembly along with cell-derived exosome mimetics (EMs). EM

DataCite2026 · Magnetic resonance imaging

This submission contains in vitro and in vivo MRI data for the article entitled "Liposomal nanoprobes actuated by engineered peptide water channels for sensitive MRI detection of molecular targets," by Das, Simon et al., in Nature Biomedical Engineering. Data included comprise raw Bruker-format MRI time series obtained from the experiments of Figures 3 and 4 in the paper, which focus on testing th

DataCite2026 · dataset

This dataset contains fluorescence microscopy video data (.avi) of DNA origami nanosprings used to measure the force generated by the kinesin-3 motor protein KIF1A. The dataset includes recordings for wild-type KIF1A and multiple disease-related KIF1A mutants (e.g., V8M, A255V, P305L), organized into separate directories. Each video captures nanospring extension under force, which can be used to q

DataCite2026 · dataset

Sepsis is an immune paradox where host defence is necessary for survival but also contributes to organ damage and death. Using lung intravital microscopy we defined an immunothrombosis cascade of neutrophil and platelets in the microcirculation in response to E. coli sepsis. Neutrophil cathelicidin localized neutrophils to E. coli and initiated founder immunothrombi via formyl-peptide receptors. I

DataCite2026 · dataset

Potato virus X (PVX), a filamentous, positive-sense RNA plant virus, has been engineered into a molecular tool for diverse biotechnological applications, including cancer cell targeting. Here, we present the production and functional characterization of genetically-encoded PVX-derived nanoparticles decorated with nanobodies targeting two common receptors in human cancer cells, epidermal growth fac

DataCite2026 · dataset

Plant virus-derived materials are finding applications in science, engineering, and technology – with some candidates advancing toward commercialization, scalable manufacturing methods are needed. We recently established ultrafiltration/diafiltration (UF/DF) for purification of cowpea mosaic virus (CPMV) and tested here broader applicability of this process by purifying cowpea chlorotic mottle vir

DataCite2026 · dataset

Previously, in human, we have shown the role of a dis-integrin and metalloproteinase (ADAM) in connexin-43 (Cx43) degradation in human heart end stage heart failure (i.e., heart failure with reduced ejection fraction, HFrEF). We also observed Cx43 degradation and blood heart barrier (BHB) leakage during HFrEF in mice. Although Cx43 coordinates mitochondrial fusion-fission with myocyte contraction-

DataCite2026 · dataset

There have been rapid advances in nucleoside-modified messenger RNA-based vaccines, particularly during the SARS-CoV2 pandemic, demonstrating a rapid and cost-effective approach for addressing infectious diseases. A major challenge remains in developing a delivery system that protects mRNA from degradation and facilitates its passage through tissue and cellular barriers. Current four-component lip

DataCite2026 · dataset

Emerging molecular therapies introduce enzymatic activity into cells by delivering genes, transcripts, or proteins. Owing to their robust cell-entry capacity, virus-like particles (VLPs) represent a technology of choice in genome editing, where low doses of heterologous proteins and nucleic acids are essential. However, clinical translation of VLP vectors is hindered by inadequate purification met

DataCite2026 · Crystal structure

CRISPR/Cas9-based gene-editing technologies offer promise for treating inherited retinal diseases (IRDs); however, safe and efficient ocular delivery of precision editors remains challenging. To address this challenge, we report a new class of Coomassie brilliant blue (CBB)-derived lipidoids that bind and deliver proteins. Subretinal injection of Cre complexed with these lipidoids into mT/mG mice

DataCite2026 · dataset

This dataset provides the source data for the paper titled "Synaptotagmin-1 serves as a primary Zn²⁺ sensor to mediate spontaneous neurotransmitter release under pathological conditions." Data includes electrophysiological patch-clamp recordings of miniature excitatory postsynaptic currents (mEPSCs), spontaneous EPSCs (sEPSCs), and evoked EPSCs, along with single-vesicle and ensemble lipid-mixing

DataCite2026 · dataset

This dataset contains quantitative measurements of skeletal muscle fiber morphology and capillarization in young and older women. Muscle biopsies were obtained from both a rested leg and a leg that had performed a single bout of heavy resistance exercise five days prior to sampling. Variables include muscle fiber cross-sectional area, perimeter, and Shape Factor Index (SFI), as well as multiple in

DataCite2026 · dataset

This dataset contains raw and processed data for a manuscript in The FEBS Journal. Nutrient depletion triggers a starvation-induced calcium (Ca2+) signal (SICS) that promotes Ca2+-dependent responses. However, the components and regulations of SICS are unclear. In this work, we explored SICS components and their regulation by the Ca2+ sensor calmodulin (CaM). The work provides molecular evidence o

DataCite2026 · dataset

This dataset contains plasma concentrations of 96 immune-related proteins measured using a custom Luminex xMAP assay in 40 women (20 with PCOS, 20 controls) matched for age, BMI, and race (Black and White). The comprehensive panel includes: Growth Factors (12): EGF, FGF-2, FLT3L, G-CSF, GM-CSF, M-CSF, PDGF-AA, PDGF-AB, SCF, TGF-α, TPO, and VEGF-A Cytokines (35): APRIL, BAFF, IFN-α2, IFN-β, IFN-γ,

DataCite2026 · dataset · unknown

This FAIRsharing record describes: KI Data Repository is the institutional data repository for Karolinska Institutet (KI). KI Data Repository accepts data where KI is the research principle, i.e. where KI is the organization responsible for the data. KI Data Repository’s mission is to curate, preserve, and provide continued access to KI’s research data.

DataCite2025 · dataset

Vascular activation is characterized by increased proinflammatory, prothrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr-abl-negative myeloproliferative neoplasms (MPNs), graft-vs-host disease, and COVID-19, have been noted to have increased activation of the Janus kinase (JAK)-signal transducer and downstream activator of transcription (STAT) pathways. Two

DataCite2025 · Crystal structure

We investigated large systems of self-driven spinners confined over a substrate through direct numerical simulation of 3D hydrodynamics. Our results demonstrated that these systems generate unique flows from which spatial and orientational order emerges. We showed that a transition in particle orientation accompanies the appearance of crystallinity as the packing fraction is increased. Further exp

DataCite2025 · dataset

Background: The main mission of NIH-sponsored institutional training programs such as the T32 is to provide strong research and career training for early career scientists, while preparing those individuals to become leaders working to meet the health-related research needs of the nation. One of the main avenues to pursue health-related research is becoming research faculty at an academic institut

DataCite2025 · dataset

Why cancer is so prevalent among mammals, despite the fact that some species evolved resistance mechanisms, remains an open question. We hypothesized that cancer prevalence and mortality risk might have been fine-tuned by evolution. Using public databases, we show that species with cooperative habits have lower cancer prevalence and mortality risk. By developing a mathematical model, we provide a