Data Sheet 1_Structural and functional characterization of the gut microbiota in women with early pregnancy loss in Northwest China.zip

Compared to NCs, the EPL group had higher relative abundances of species such as Bacteroides stercoris, Bacteroides plebeius, and Bacteroides uniformis, but lower relative abundances of Bifidobacterium adolescentis, Megamonas funiformis, and Fusicatenibacter saccharivorans. Partial correlation analysis showed that Bacteroidetes was positively correlated with EPL at the phylum level. At the genus level, Odoribacter, Parabacteroides, and Haemophilus were positively correlated with EPL, whereas Corynebacterium, Lactobacillus, and Roseburia were negatively correlated with EPL.

Metabolic pathway analysis revealed that pathways such as L-rhamnose degradation I, L-arginine biosynthesis III and 2-oxobutanoate degradation I exhibited significant positive correlations with EPL. In contrast, pathways including purine nucleobases degradation I (anaerobic) and chitin derivatives degradation showed significant negative correlations with EPL.</p>Conclusion<p>The results of our study revealed significant differences in gut microbiota composition and metabolic pathways between the EPL group and NCs, indicating that gut microbiome alterations are associated with EPL.</p>