Data · study · 2026
CSF2 knockdown alters gene expression profiles in BCPAP papillary thyroid carcinoma cells
Listed in NCBI GEO
This study investigates the transcriptomic changes in BCPAP papillary thyroid carcinoma (PTC) cells following CSF2 knockdown using Affymetrix PrimeView Human Gene Expression Array.
Description
CSF2 knockdown was achieved via shRNA, with non-targeting shRNA as control. Three biological replicates per group were analyzed.
Results show that CSF2 regulates genes involved in cell proliferation, invasion, and metastasis, particularly through the STAT3-CXCL5-WNT/beta-catenin axis. Our findings provide insights into CSF2 as a potential therapeutic target in PTC progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330622 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330622 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1464708 ncbi.nlm.nih.gov/bioproject/PRJNA1464708 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330622 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |