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}NCBI GEO2026 · study · 14 samples
Gene expression profiling of mouse placenta following prenatal cannabis smoke exposurePrenatal cannabis use is increasing, yet the effects of inhaled cannabis smoke on placental molecular function remain poorly defined. The goal of this study was to characterize placental transcriptomic alterations following prenatal cannabis smoke exposure using a physiologically relevant inhalation model. Timed-pregnant CD1 mice were exposed to cannabis cigarette smoke or room air from embryonic
NCBI GEO2026 · study · 20 samples
Transcriptome profiling of peripheral blood mononuclear cells from patients with alcohol-related hepatitis following antioxidant and trace element supplementationThis study investigated the effects of antioxidant and trace element supplementation on gene expression in peripheral blood mononuclear cells (PBMCs) from patients with alcohol-related hepatitis. PBMCs from 10 patients were cultured for 48 hours with no supplementation or supplemented with N-acetylcysteine (NAC), selenium or zinc sulfate. Genome-wide gene expression was assessed using the Affymetr
NCBI GEO2026 · study · 26 samples
Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipose Progenitor Self-Renewal and Adipogenic DifferentiationProlonged tamoxifen treatment for estrogen receptor positive breast cancer disrupts estrogen receptor signaling in subcutaneous adipocytes and downregulates Wnt1-inducible signaling pathway protein 2 (Wisp2/Ccn5), a key regulator of progenitor cell maintenance. The resulting reduction in cell proliferation, impaired self renewal of progenitors, and reduced adipogenic differentiation by tamoxifen p
NCBI GEO2026 · study · 15 samples
Expression data from mice serotonin neurons in the dorsal raphe nucleus (DRN)Numerous reports have demonstrated the critical role of the serotonin system originating from the dorsal raphe nucleus (DRN) in stress resiliency as well as stress coping. It have been demonstrated that the activity of DRN serotonin neurons is decreased by chronic stress and is increased by chronic treatment with antidepressants, which renders stress resiliency. Mechanistically, it have been repor
NCBI GEO2026 · Text · 38 samples
Transcriptional profiling of the effects of HDAC4 or HDAC5 knockdown in uveal melanoma cell lines with monosomy of chromosome 3 (M3) and BAP1 mutations or disomy of chromosome 3 (D3) and wild-type BAP1Monosomy of chromosome 3 (M3) and mutations in BAP1 are strongly associated with metastatic risk in uveal melanoma. We aimed to investigate the roles of HDAC4 and HDAC5 in uveal melanoma cell lines with differential status of chromosome 3 and BAP1. We compared gene expression after shRNA knockdown of HDAC4 or HDAC5, respectively, in two uveal melanoma cell lines with monosomy of chromosome 3 (M3)
NCBI GEO2026 · Excel spreadsheet · 6 samples
GD3 synthase deficiency in mouse brainThe objective was to identify changes in gene expression in cerebellar tissue in GD3S-/- (St8sia1 null) vs WT mice.
NCBI GEO2026 · study · 10 samples
Westernized diet related arachidonic acid metabolism expands DNA error-prone growth factor-dependent colonic quiescent stem cells in adolescent mice [Affymetrix Array]Given the association between early-onset colorectal cancer (eoCRC) and insulin resistance (IR), we investigated the effects of westernized diet (WD)-induced IR on intestinal stem cells (ISCs) by in-depth phenotyping three adolescent mouse models of escalating WD-driven IR. WD-related hyperlipidaemia and hyperglycaemia enhanced ω6-polyunsaturated fatty acid (PUFA) metabolism, while inhibiting gluc
NCBI GEO2026 · study · 24 samples
Integrated Skin and Liquid Biopsy Immune Modules for Molecular Diagnosis of Cutaneous T Cell LymphomaCutaneous T-cell lymphomas (CTCL) present a diagnostic challenge due to substantial clinical overlap with benign inflammatory conditions, stressing the need for a deeper understanding of disease-specific immune dysregulation. Here, we define CTCL-specific malignant inflammation (MI) signatures in skin and blood enabling clear diagnosis from benign inflammatory dermatoses.
NCBI GEO2026 · study · 12 samples
Cxcr2 deficiency alters transcriptional programs in articular cartilage and subchondral bone of adult male miceC-X-C chemokine receptor 2 (CXCR2) regulates leukocyte trafficking and inflammatory signaling, but its contribution to skeletal homeostasis across bone-related tissues is incompletely understood. We profiled gene expression in femoral head articular cartilage and knee subchondral bone from adult male Cxcr2-null mice and wild-type littermate controls using Clariom S Mouse microarrays. The microarra
NCBI GEO2026 · Text · 12 samples
Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodelingMetabolic dysfunction and alcohol exposure drive steatotic liver disease, yet how ethanol intersects with metabolic steatohepatitis remains incompletely defined. Our iterative model examined how ethanol ingestion alters high-fat, -fructose, and -cholesterol (FFC)-driven liver injury, identifying MetALD-relevant features. A pilot study in male and female C57BL/6J mice compared chow diet (CD), FFC,
NCBI GEO2026 · study · 303 samples
Development and validation of a prognostic gene expression model for second primary malignancy in head and neck squamous cell carcinomaSecond primary malignancy (SPM) and local recurrence (LR) are linked to poor prognosis in head and neck squamous cell carcinoma (HNSCC), highlighting the need for early detection in the successful management of HNSCC patients. This study aimed to develop prognostic models for predicting time to SPM and LR. A retrospective cohort of 1,113 HNSCC patients (2008–2019) was analyzed. Gene expression dat
NCBI GEO2026 · Non-coding RNA profiling by array · 115 samples
B-cell cancer cell linesThis SuperSeries is composed of the SubSeries listed below.
NCBI GEO2026 · study · 3 samples
Transcriptional landscape of Mycobacterium tuberculosis during active pulmonary tuberculosis in rabbitsMycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis that kills millions of people each year, primarily infects the lungs. However, the bacterial adaptation during active tuberculosis in the lungs is not fully understood. Here, we report the transcriptional landscape of Mtb in the lungs of infected rabbits, compared to their growth in vitro in broth culture. Identification and cha
NCBI GEO2026 · Text · 6 samples
Reduced glutathione levels in Enterococcus faecalis trigger metabolic and transcriptional compensatory adjustments during iron exposure.Enterococcus faecalis, a facultative anaerobic pathogen and common constituent of the gastrointestinal microbiota, must navigate varying iron levels within the host. This study investigates the bacterium's response to elevated iron levels in the context of glutathione deficiency, a critical low molecular weight antioxidant synthesized within cells. We examined the transcriptomic and metabolic resp
NCBI GEO2026 · study · 34 samples
Expression data from B-cell cancer cell lines [HGU133]In this study, we introduce a data-comprehensive human B-cell cancer cell line (HBCCL) panel comprising 17 diffuse large B-cell lymphoma (DLBCL) cell lines and 18 multiple myeloma (MM) cell lines. The panel includes integrated datasets from drug dose–response screens (11 agents), gene expression profiling, and quantitative proteomics. The utility of this resource is illustrated with examples of an
NCBI GEO2026 · Text · 8 samples
iMSC-derived extracellular vesicles and their miRNA cargo influence inflammation and oxidative damage in an in vitro osteoarthritis modelOsteoarthritis is a multifactorial chronic joint disease characterized by progressive cartilage degradation and relevant inflammation. Since there is no effective cure, emerging therapeutic approaches, such as mesenchymal stromal cells (MSCs) transplantation, are currently under investigation. However, the clinical translation of MSC-based therapies is hampered by several limitations, such as dono
NCBI GEO2026 · study · 4 samples
An analysis of gemcitabine-resistant cholangiocarcinoma cellsCholangiocarcinoma (CCA) is an aggressive liver bile duct cancer with a poor prognosis. For advanced CCA patients, Gemcitabine (GEM)-based chemotherapy is the standard treatment. Since there is only a 20-30% response rate for advanced CCA patients, it is a critical issue to counteract GEM resistance (GR). We selected two GR iCCA sublines (SSP-25-GR and SNU-1196-GR) from the parental cells (SSP-25
NCBI GEO2026 · study · 6 samples
Expression data from human embryonic stem cell aggregates treated with CHIR99021The yolk sac is a vital extraembryonic organ that supports embryonic development during early gestation, before the placenta assumes many of its supportive functions. Abnormal development or function of the yolk sac can lead to embryonic demise or developmental abnormalities. However, the genetic and environmental factors that impair human yolk sac development and function remain poorly understood
NCBI GEO2026 · Text · 21 samples
Spatial Transcriptomics Reveals that a Novel Microporous [nCounter]Full-thickness burns frequently lead to scarring and long-term functional impairment driven by aberrant extracellular matrix (ECM) remodeling. Although split-thickness skin grafting (STSG) is the clinical standard, complete restoration of normal skin architecture is not always achieved. Biomaterial wound matrices can supplement grafting, yet how material architecture shapes spatially resolved cell
NCBI GEO2026 · study · 28 samples
Effect of strenuous exercise in gene expression of both atria of female rats.Strenuous exercise increases the risk of atrial fibrillation in male athletes and trained male individuals, at least partially mediated by atrial fibrosis and parasympathetic tone enhancement, However, whether women athletes are at an increased risk of atrial fibrillation remains uncertain. We aimed to analyze biatrial remodeling after strenuous exercise in female rats, and compare results to thos
NCBI GEO2026 · study · 12 samples
Tlr4 Epidermal Genetic Deletion Protects Against Acute and Tumorigenic UV Exposure in SKH-1 Mouse SkinSolar ultraviolet (UV) exposure activates Toll-Like Receptor 4 (TLR4), initiating inflammatory signaling pathways relevant to human skin carcinogenesis. Using transcriptomic (Nanostring-based) and proteomic (reverse phase protein array-based) analysis we demonstrate that genetic deletion of epidermal Tlr4 mimics the photoprotective impact of pharmacological antagonism using topical resatorvid (RES
NCBI GEO2026 · study · 8 samples
TrkC-dependent regulation of dendritic branching shapes dendritic bundle architecture in the rat granular retrosplenial cortex.Cortical modules are thought to provide anatomical frameworks for local microcircuits. However, the mechanisms regulating the morphological organization of these modules during development remain poorly understood. In the rat granular retrosplenial cortex, layer 1 contains prominent dendritic bundle-centered modules formed by the apical dendrites of layer 2 neurons and aligned with specific affere
NCBI GEO2026 · Table · CSV · 8 samples
ceRNA expression profiling of sunitinib-resistant and parental clear cell renal cell carcinoma cellsTo identify circular RNAs associated with sunitinib resistance in clear cell renal cell carcinoma, ceRNA expression profiles were compared between parental 786-O cells and sunitinib-resistant 786-OR cells using a one-color human ceRNA microarray. Differential expression analysis identified resistance-associated circRNAs, including circLAMA5 (hsa_circ_0061093), for subsequent functional and mechani
NCBI GEO2026 · study · 60 samples
Anti-Notch plus endocrine therapy in ER+ breast cancer inhibits cancer stem cells by increasing DAXXResistance to endocrine therapy (ET) in ER+ breast cancer is mediated by Notch signaling, but the clinical application of anti-Notch therapy has been limited by the lack of predictive biomarkers. To identify Notch-regulated biomarkers, we conducted a pre-surgical window study evaluating ET combined with the γ-secretase inhibitor (GSI) MK-0752. RNA expressions in tumors were measured using an Affym
NCBI GEO2026 · study · 5 samples
CD4 T cell subset mRNA expression microarrayEx vivo CD4 T cell subsets from 1 donor was used for affimterix microarray screen We used microarary to comapre differential expressed genes between CD4 T cell subsets with a focus on Tregs