Omics · study · 2026
Epigenetic and Immunological Alterations in Umbilical Cord Blood of Overweight/Obese Women with Gestational Diabetes Mellitus: Insights into DNA Methylation Signatures and Immune Cell Dysregulation
Listed in NCBI GEO
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication with significant maternal and fetal health implications.
Description
This study examines the impact of overweight/obesity-related GDM on DNA methylation and immune function in umbilical cord blood. Using an 850K methylation array, we identified 23,331 hypermethylated and 29,501 hypomethylated differentially methylated positions (DMPs), with hypomethylation being predominant.
Functional enrichment analysis linked these alterations to neurodevelopment, metabolism, immune regulation, and epigenetic control. Immune profiling revealed a significant reduction in CD4+ T cells (p < 0.05), a trend toward decreased NK cells, and increased CD8+ T cells and neutrophils in GDM cases, findings confirmed by single-cell RNA sequencing. Lasso regression identified seven key CpG sites associated with immune composition and metabolic parameters, forming a GDM risk prediction model with an AUC of 100%.
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These results highlight epigenetic dysregulation and immune alterations in GDM, providing potential biomarkers for early screening and personalized interventions.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290728 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290728 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1229649 ncbi.nlm.nih.gov/bioproject/PRJNA1229649 ↗
project · from NCBI GEO
- PubMed 42343321 pubmed.ncbi.nlm.nih.gov/42343321 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 65% · Genetics 73% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290728 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |