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Data · dataset · 2025

Virome profile in acute febrile illness patients using metagenomic Next-Generation Sequencing: A systematic review, meta-analysis and Torque Teno Virus abundance in Northeastern Thailand

Listed in Teesside University Research Data Repository

This study aimed to identify viruses present in AFI patients via metagenomic next-generation sequencing (mNGS) through meta-analysis.

Description

The publications were retrieved from three databases, including PubMed, Scopus and ScienceDirect. Five publications [1-5] that met our specific inclusion criteria and used mNGS to examine the virome in AFI plasma and serum specimens were eligible for this systematic review.

The sample size of the studies included in this meta-analysis varied significantly, ranging from 12 to 816 cases. Of the five studies were cross-sectional studies. All three studies reported detailed information on the age distribution of AFI patients.

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The geographical distribution of the study population was two studies conducted in America, one in Africa and two in Europe. All studies used plasma or serum for the NGS method, with or without RT-PCR. References 1.

Yozwiak, N. L., Skewes-Cox, P., Stenglein, M. D., Balmaseda, A., Harris, E., & DeRisi, J. L. Virus identification in unknown tropical febrile illness cases using deep sequencing. PLoS neglected tropical diseases. 6(2), e1485 (2012). 2. Sardi, S. I. et al. Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing.

Journal of clinical microbiology. 54(9), 2348–2353 (2016). 3. Williams, S. H. et al. Investigation of the Plasma Virome from Cases of Unexplained Febrile Illness in Tanzania from 2013 to 2014: a Comparative Analysis between Unbiased and VirCapSeq-VERT High-Throughput Sequencing Approaches. mSphere. 3(4), e00311-18 (2018). 4. Jerome, H. et al. Metagenomic next-generation sequencing aids the diagnosis of viral infections in febrile returning travellers.

The Journal of infection. 79(4), 383–388 (2019). 5. Cordey, S. et al. Blood virosphere in febrile Tanzanian children. Emerg Microbes Infect. 10(1), 982-993 (2021).

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Where it is published

Catalogue records · 1

Topics

From keywords
Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Inferred from text
Bioinformatics and computational biology 69% · Sequencing 75%
Provenance · 1 source records, 12 field assertions
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