Omics · study · 2026
RNA seq of peripheral blood mononuclear cells in mice after sepsis modeling
Listed in NCBI GEO
This study focuses on analyzing the gene expression profiles of peripheral blood mononuclear cells (PBMCs) in mice following the induction of sepsis, using RNA sequencing (RNA-seq).
Description
PBMCs play a central role in the immune response, and their transcriptional changes can provide critical insights into the systemic immune dysregulation that occurs during sepsis. By identifying key genes and pathways that are altered in response to sepsis, this research aims to uncover molecular mechanisms driving disease progression and immune dysfunction.
The findings could pave the way for the development of targeted therapies or diagnostic biomarkers to improve the management and treatment of sepsis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296770 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296770 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1261017 ncbi.nlm.nih.gov/bioproject/PRJNA1261017 ↗
project · from NCBI GEO
- PubMed 41698047 pubmed.ncbi.nlm.nih.gov/41698047 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE296770 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |