← Search

Data · study · 2026

The effect of TCOF1 silencing in renal cancer cells

Listed in NCBI GEO

TCOF1 is a nucleolar protein involved in ribosome biogenesis, response to DNA damage and oxidative stress.

Description

Clear cell renal cell cancer (ccRCC) is characterized by pronounced nucleolar pleomorphism which is utilized in the ccRCC tumor grading system. Here, we hypothesized that TCOF1 may contribute to the tumorigenesis of ccRCC.

To explore the impact of TCOF1 on ccRCC, we silenced its expression in ccRCC cells and analyzed their transcriptome using microarrays.

Links

Get the data

Where it is published

Documentation and papers

Topics

Stated by source
Expression profiling by array · Homo sapiens
From keywords
Life Sciences
Inferred from text
Cancer 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE29958015 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-arraysource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title