Omics · study · 2026
Transcriptomic profile of Chronic Hepatitis B patients positive for pregenomic RNA.
Listed in NCBI GEO
In this cohort, we aimed to study the transcriptomic profile of CHB (Chronic Hepatitis B) HBeAg negative patients treated with Nucleoside Analog (NAs) and examined for the HBV transcriptional maintenance after tested for the pregenomic RNA (pgRNA) index.
Description
Twelve HBeAg negative CHB patients, who receive long-term treatment with NAs were included. Plasma samples were quantified by Polymerase Chain Reaction (PCR) for the presence of pgRNA and RNA extraction was performed for analysing the transcriptomic profile through RNA sequencing.
A total of 18.1% of our sample was positive for HBV pgRNA, delineating a positive correlation with cirrhosis and an apparently negative correlation with therapy duration. HBV pgRNA seems to be a valuable non invasive biomarker, delineating the transcriptional status of the HBV in the liver, even under normal biochemical conditions. The transcriptomic profile of HBV pgRNA positive patients could delineate novel pathways related to cirrhosis and HCC development on CHB patients.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316961 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316961 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1405602 ncbi.nlm.nih.gov/bioproject/PRJNA1405602 ↗
project · from NCBI GEO
- PubMed 42440489 pubmed.ncbi.nlm.nih.gov/42440489 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316961 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |