Omics · study · 2026
MeRIP-seq study of Vaccinia virus-infected Vero cell
Listed in NCBI GEO
We aimed to understand the dynamic interplay between host and virus by investigating transcriptomic and epitranscriptomic dynamics in the Vero E6 cells during Vaccinia Virus infection.
Description
In this study, we characterized N6-methyladenosine (m6A) modifications, pivotal regulators of transcript lifecycle, throughout three different post-infection time points using RNA-seq and m6A RNA immunoprecipitation sequencing (MeRIP-seq).
We identified changes in host m6A epitranscriptome in the early phase of viral infection, which includes genes involved in host immunity, RNA biosynthesis, and protein ubiquitination. Leveraging temporal analysis of host transcriptomic and epitranscriptomic landscapes, this study offers a novel insight into the host-virus interaction, emphasizing the importance of RNA modifications in host transcripts as an early response to viral infection.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284044 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284044 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1190593 ncbi.nlm.nih.gov/bioproject/PRJNA1190593 ↗
project · from NCBI GEO
- PubMed 41965674 pubmed.ncbi.nlm.nih.gov/41965674 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Other
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 71% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE284044 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |