Omics · study · 2026
GLAST-positive small extracellular-vesicle total-RNA sequencing in amyotrophic lateral sclerosis: a 60-participant discovery cohort
Listed in NCBI GEO
Total-RNA sequencing of a plasma-derived, GLAST-positive small extracellular-vesicle fraction was performed in a discovery cohort of 60 participants, including 45 participants with amyotrophic lateral sclerosis (ALS) and 15 non-neurological controls.
Description
One total-RNA sequencing library was generated per participant using the SMARTer Stranded Total RNA-Seq Kit v3 – Pico Input Mammalian and sequenced on an Illumina NovaSeq 6000 at the Yale Center for Genome Analysis.
This Series contains the total-RNA sequencing data. Matched small-RNA sequencing was performed from the same vesicle RNA eluate and is deposited in a companion GEO Series. The data were generated to characterize extracellular-vesicle RNA cargo and identify molecular features associated with ALS and clinical progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346896 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346896 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1526785 ncbi.nlm.nih.gov/bioproject/PRJNA1526785 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346896 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |