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Omics · study · 2026

Cellular Landscape During Ovalbumin-Induced Allergic Lung Inflammation [scRNA-Seq]

Listed in NCBI GEO

Cyclooxygenase-2 (COX-2) is a critical enzyme that helps regulate allergic responses by converting arachidonic acid (AA) into lipid-based compounds called prostaglandins (PGs), which play a key role in maintaining lung function.

Description

To better understand how COX-2-derived PGs influence allergic reactions in allergic lung inflammation, we analyzed transcriptomic changes in wild-type (COX-2+/+) and COX-2-/- mice sensitized with the allergen ovalbumin (OVA) using single-cell RNA sequencing

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Expression profiling by high throughput sequencing · Mus musculus
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Life Sciences
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RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE31874214 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:single-cell-rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title