Excel · study · 2026
Gene expression profiling of H23 lung adenocarcinoma cells treated with sotorasib and linsitinib alone or in combination
Listed in NCBI GEO
KRAS G12C inhibitors have improved the treatment of KRAS G12C-mutant lung cancer; however, adaptive resistance limits their long-term efficacy.
Description
To investigate the transcriptional effects of combined KRAS and IGF1R inhibition, we performed RNA sequencing of the KRAS G12C-mutant lung adenocarcinoma cell line H23 following treatment with sotorasib, linsitinib, or their combination. This dataset provides genome-wide gene expression profiles associated with single-agent and combination treatments and may facilitate the identification of molecular mechanisms underlying the enhanced antitumor effects of combined KRAS and IGF1R inhibition.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342646 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342646 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1508685 ncbi.nlm.nih.gov/bioproject/PRJNA1508685 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342646 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |