← Search

Table · dataset · 2026

Supplementary file 1_Disease-modifying therapies are associated with improved olfactory function via NK cell- microbiota interactions in multiple sclerosis.doc

Listed in figshare

Objective<p>To examine the associations of nasal microbiota with disease-modifying therapies (DMTs), lymphocyte subsets and olfactory function in multiple sclerosis (MS).</p>Methods<p>Thirty patients with MS and 30 age- and sex-matched healthy controls (HCs) were enrolled.

Description

Patients were classified as DMT-treated (MS[DMT+]) or untreated (MS[DMT-]). Olfactory function was assessed using the University of Pennsylvania Smell Identification Test (UPSIT).

Lymphocyte subsets were measured by flow cytometry, and nasal microbiota were analysed by 16S rRNA sequencing.</p>Results<p>Olfactory function was lower in MS than in HCs, and better in MS(DMTs+) than in MS(DMTs−) (p =0.016, 95% CI 0.5614 to 4.941). NK cell counts were lower in MS(DMTs+) than in MS(DMTs−) (p =0.049, 95% CI -244.7 to -0.2109). And NK cell counts in MS(DMTs+) correlate with UPSIT (r =-0.527, p =0.029).

Read the rest (1 more)

Compared with HCs, MS(DMTs−) showed higher Shannon diversity (p =0.038), increased Proteobacteria (p =0.004), reduced Moraxellaceae (p =0.037) and Enterobacteriaceae (p =0.033), and enriched branched-chain amino acid biosynthesis (p =0.026). In MS(DMTs+), Campylobacter, Anaerococcus, Peptoniphilus, Prevotella, and Finegoldia were positively correlated with circulating NK cells (all p<0.05).</p>Conclusion<p>DMTs may improve olfactory function in MS, possibly through modulation of circulating NK cell-associated immune status and nasal microbiota, in addition to controlling disease-related inflammation.</p>

Links

Where it is published

Catalogue records · 1

Topics

From keywords
Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Medicine & Health · Ocean & Atmospheric Science · Social Science
Inferred from text
Immunology 69% · Sequencing 75%
Provenance · 1 source records, 18 field assertions
SourceKeyLast seenRaw
figshareoai:figshare.com:article/3371896011 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · figshare comconnector:figshare_com@1.0.0
concepts[field].anzsrc:group:3204enrichment · figshare comtaxonomy-embedding@1.0.0title+keywords+description (69%)
concepts[field].local:field:astronomymapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:chemistrymapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:computer-science-aimapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:earth-environmentalmapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:economics-financemapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:engineeringmapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:humanitiesmapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:life-sciencesmapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:medicine-healthmapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:ocean-atmosphericmapping · figshare comconnector:figshare_com@1.0.0
concepts[field].local:field:social-sciencemapping · figshare comconnector:figshare_com@1.0.0
concepts[modality].local:modality:sequencingenrichment · figshare comkeyword-concept-rules@1.0.0title+description (75%)
descriptionsource · figshare comconnector:figshare_com@1.0.0/metadata/dc/description
licensesource · figshare comconnector:figshare_com@1.0.0/metadata/dc/rights
publication_datesource · figshare comconnector:figshare_com@1.0.0
titlesource · figshare comconnector:figshare_com@1.0.0/metadata/dc/title