Data · study · 2026
Characterization of resistance to the KRAS inhibitor sotorasib in KRASG12C-positive non-small cell lung cancer (NSCLC) cells
Listed in NCBI GEO
Inhibitors of KRAS show clinical efficacy for non–small cell lung cancer (NSCLC) positive for the G12C mutation of KRAS, but primary and acquired resistance to these drugs remains a major clinical problem.
Description
Activation of EGFR signaling via the MAPK pathway is a key mechanism of such resistance. We used expression data to understand the gene expression profile and identified distinct charactersitics on resistance cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295133 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295133 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1253596 ncbi.nlm.nih.gov/bioproject/PRJNA1253596 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE295133 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |