Omics · study · 2026
A Neutrophil Membrane-Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders
Listed in NCBI GEO
Perioperative neurocognitive disorder (PND) is a common neurological complication following surgery in elderly individuals and is closely associated with neuroinflammation and blood-brain barrier disruption.
Description
In this study, we investigated hippocampal transcriptomic alterations in aged mice subjected to tibial fracture surgery and evaluated the therapeutic effects of a neutrophil membrane-encapsulated Pd/hCeO2 nanoformulation (PCN).
Bulk RNA sequencing was performed on hippocampal tissues collected from Control, PND, and PCN-treated mice. Differential gene expression and pathway enrichment analyses were conducted to identify molecular mechanisms involved in surgery-induced neuroinflammation and the therapeutic actions of PCN. These data provide a transcriptomic resource for understanding the pathogenesis of PND and the mechanisms underlying PCN-mediated neuroprotection.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339068 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339068 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1496911 ncbi.nlm.nih.gov/bioproject/PRJNA1496911 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE339068 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |