Omics · study · 2026
The ‘Metabolic Trap’: Candida parapsilosis Inhibits Staphylococcus aureus Biofilm Maturation by Disrupting pH Homeostasis and Inducing Premature Exodus
Listed in NCBI GEO
Biofilms are surface-attached communities of microorganisms surrounded by an extracellular matrix.
Description
The biofilm matrix plays an integral role in protecting the microorganisms within. Biofilm infections are incredibly difficult to treat.
Staphylococcus aureus is a major human pathogen and can produce robust biofilm. Candida parapsilosis is an emerging fungal pathogen that is frequently isolated as the cause of infection. Its interaction with S. aureus has yet to be explored.
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The aim of this experiment was to characterise the transcriptional effects that occur in S. aureus during co-culture with C. parapsilosis cells or C. parapsilosis cell-free supernatant. RNA sequencing identified global changes in transcription that occur in S. aureus in the presence of C. parapsilosis cells or cell-free supernatant.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334781 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334781 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1476492 ncbi.nlm.nih.gov/bioproject/PRJNA1476492 ↗
project · from NCBI GEO
- PubMed 42519881 pubmed.ncbi.nlm.nih.gov/42519881 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334781 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |