Omics · study · 2026
Transcriptomic analysis of cold-acclimated D10 T cells
Listed in NCBI GEO
T cells are highly sensitive to temperature changes, and low temperatures markedly affect their motility and functional behavior.
Description
In this study, we performed RNA sequencing to investigate transcriptomic changes associated with cold acclimation in T cells. D10 CD4⁺ helper T cells were cultured at either 37°C or cold-acclimated at 26°C for 24 hours, followed by RNA extraction and high-throughput sequencing.
Comparative transcriptomic analysis was conducted to identify genes and biological pathways regulated by cold acclimation. This dataset provides a resource for understanding molecular responses of T cells to sustained low-temperature exposure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316736 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316736 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1404103 ncbi.nlm.nih.gov/bioproject/PRJNA1404103 ↗
project · from NCBI GEO
- PubMed 42099603 pubmed.ncbi.nlm.nih.gov/42099603 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316736 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |