Omics · study · 2026
Deciphering lineage decision of hematopoietic stem cells at homeostasis and aging
Listed in NCBI GEO
To revealed the mechanism of long-term hematopoietic stem cells (LT-HSCs) lineage decision and bias during aging, we applied scRNA sequencing with three sub-clusters within the compartment in different age groups, namely CD150hiSca1hi LT-HSCs, CD150hiSca1lo LT-HSCs and CD150lo LT-HSCs.
Description
These three LT-HSC subsets encompass a spectrum of lineage specification and commitment cell states, which were further segregated into 6 different clusters.
Characterization of the self-renewal capacity and lineage potential of the quiescence HSC subpopulation by transplantation assays revealed the identity of bona fide HSC (Meg3+-HSC), which expanded dramatically started at middle-age, with dynamic transcriptional activities associated with protein modification and platelets activation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE263nnn/GSE263781 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE263781 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1074098 ncbi.nlm.nih.gov/bioproject/PRJNA1074098 ↗
project · from NCBI GEO
- PubMed 42191895 pubmed.ncbi.nlm.nih.gov/42191895 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 69% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE263781 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |