Omics · study · 2026
RNA-seq analysis of FOXA1 and TRIM28 knockdown in LNCaP prostate cancer cells
Listed in NCBI GEO
This study investigates transcriptomic changes following knockdown of FOXA1 or TRIM28 in LNCaP prostate cancer cells.
Description
LNCaP cells were transduced/transfected with shRNAs targeting FOXA1 or TRIM28, along with corresponding negative control shRNAs. Total RNA was extracted from biological replicates and subjected to high-throughput RNA sequencing.
Differential gene expression analysis was performed to identify genes and pathways affected by FOXA1 or TRIM28 depletion. This dataset provides a resource for studying the transcriptional regulatory roles of FOXA1 and TRIM28 in prostate cancer cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343103 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343103 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1510517 ncbi.nlm.nih.gov/bioproject/PRJNA1510517 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343103 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |