Data and code for metabolic decompensation under co-occurring thermal-hypoxic stress in Pacific oysters

<p dir="ltr">Processed data and analysis workflows supporting the study “Metabolic decompensation under co-occurring thermal-hypoxic stress: ESRRA alternative splicing drives non-additive oyster responses to coastal compound climate stress.” The package includes environmental temperature, salinity, and dissolved-oxygen data for oyster-associated shallow habitats (1995–2025), RNA-seq and ATAC-seq matrices from Pacific oyster gill tissues, sample metadata, peak annotations, survival-analysis code, RNA-seq and ATAC-seq workflow documentation, RNA–ATAC integration instructions, and ESRRA structural-modeling and molecular-docking workflows.

Treatment groups are normoxic control (C), heat (H), hypoxia (L), and combined heat–hypoxia (HL). RNA-seq includes 39 libraries sampled at baseline and 6, 24, 48, and 72 h; ATAC-seq includes one control library and six 48-h libraries. Raw sequencing data are available from NCBI SRA under PRJNA1509994.