Omics · study · 2026
Single-cell RNA sequencing of stem cell–like memory T (Tscm) cells from rheumatoid arthritis patients and healthy controls
Listed in NCBI GEO
Stem cell–like memory T (Tscm) cells are a subset of T cells with self-renewal capacity and multipotent differentiation potential upon antigen stimulation.
Description
Tscm cells have been implicated in the pathogenesis of autoimmune diseases. In this study, we performed single-cell RNA sequencing using the 10x Genomics platform on Tscm cells enriched by fluorescence-activated cell sorting (FACS).
Our objective was to characterize the transcriptomic signatures of Tscm cells in patients with rheumatoid arthritis (RA) and to identify disease-specific features that may contribute to RA pathogenesis and progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309906 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309906 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1363977 ncbi.nlm.nih.gov/bioproject/PRJNA1363977 ↗
project · from NCBI GEO
- PubMed 42309459 pubmed.ncbi.nlm.nih.gov/42309459 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309906 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |