Differentially expressed genes (DEGs) in HEK-293T cells treated with the culture supernatant of yeast-form Candida albicans

In this study, we investigated the transcriptional impact of yeast-form C. albicansculture supernatant on human embryonic kidney (HEK)-293T cells. HEK-293T cells were treated with the supernatant, followed by RNA sequencing (RNA-seq) to identify differentially expressed genes (DEGs).

Transcriptomic profiling revealed a distinct gene expression signature in treated cells compared to controls. Functional enrichment analysis of these DEGs highlighted significant modulation of pathways associated with cellular stress responses and signal transduction. These findings provide a comprehensive genomic landscape of the host cell response to soluble factors derived from the yeast-form C. albicans, offering insights into the molecular mechanisms underlying fungus-host cell interactions at the transcriptional level.