A Single-Cell Transcriptomic Dataset of the Neonatal Mouse Cortex Following Tenascin-C Deletion

Each sequencing sample was generated by pooling dorsal cortical tissues from at least six littermate pups.The Tnc conditional knockout model was generated on a C57BL/6JCya background using the C57BL/6JCya-Tncem1flox/Cya conditional knockout strain.

The engineered Tnc allele contains loxP sites flanking the targeted region, enabling Cre-mediated deletion. Tnc was conditionally deleted using Emx1-Cre, resulting in conditional deletion of Tnc in the dorsal cortex.This dataset enables investigation of cell-type-specific transcriptional changes associated with Tnc loss during early postnatal cortical development.Dataset ContentsThis dataset includes:Raw sequencing data for all samples in compressed FASTQ (.fastq.gz) format.MD5 checksum files corresponding to each FASTQ file for file integrity verification.File FormatEach biological replicate is stored in a separate folder.