A new myrsinol-type diterpene polyester from Euphorbia dracunculoides Lam

A new myrsinol-type diterpene polyester, 14-deoxo-3β- O -propinoyl-2α,5α,7β,15β-tetra- O -acetyl-14α- O -benzoyl-myrsinol ( 1 ), and its known analogue, 14-deoxo-3β- O -prorionyl-5α,15β-di- O -acetyl-7β- O -nicotinoyl-myrsinol-14β-acetate ( 2 ), together with a monoterpenoid, pubinernoid A ( 3 ), two indole alkaloids, neoechinulin A ( 4 ) and dihydroxyisoechinulin A ( 5 ), two benzene derivatives, siringin ( 6 ) and (3-methoxyphenyl) acetic acid ( 7 ), were isolated from the 70% acetone extract of the aerial parts of Euphorbia dracunculoides Lam.

Their structures were elucidated on the basis of spectroscopic evidence and comparison with literature reports. The absolute configuration of 1 was deduced by comparing experimental and calculated ECD spectra. Among them, compounds 4 and 5 were first obtained from the plant source.